Physiologically activated phase transition systems for improved ocular retention of ketorolac tromethamine
نویسندگان
چکیده
منابع مشابه
Ocular pharmacokinetics of 0.45% ketorolac tromethamine
PURPOSE A new carboxymethylcellulose (CMC)-containing ophthalmic formulation of 0.45% ketorolac, pH 6.8 (Acuvail(®)) was recently developed for treatment of inflammation and pain after cataract surgery. This study compared pharmacokinetics of the new formulation with that of a prior formulation, 0.4% ketorolac, pH 7.4 (Acular LS(®)). METHODS Ketorolac formulations were administered bilaterall...
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The partial phase behavior of systems composed of lecithin/isopropyl myristate (IPM)/water or ketorolac tromethamine (KT) solutions (2.5, 5, 10 and 50% w/w) at various lecithin/IPM weight ratios (km) have been investigated by the construction of phase diagrams. A commercially available soybean lecithin (namely, Epikuron 200, phosphatidylcholine purity greater than 95%) was used in this study. P...
متن کاملLecithin - Stabilized Microemulsion: An Organogel for Topical Application of Ketorolac Tromethamine. I: Phase Behavior Studies
The partial phase behavior of systems composed of lecithin/isopropyl myristate (IPM)/water or ketorolac tromethamine (KT) solutions (2.5, 5, 10 and 50% w/w) at various lecithin/IPM weight ratios (km) have been investigated by the construction of phase diagrams. A commercially available soybean lecithin (namely, Epikuron 200, phosphatidylcholine purity greater than 95%) was used in this study. P...
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Microparticles loaded gels (MPLGs) are colloidal drug carriers in the microand submicron range. These systems were developed to overcome solubility problems of poorly soluble drugs as well as for long acting injectable depot formulations and specific drug targeting options. The main objective for these systems was to improve the classical aqueous eye drop formulations which have major disadvant...
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This case report describes a general anesthetic where ketorolac tromethamine was used instead of a narcotic. The patient was a 37-year-old male, ASA II category, who underwent general anesthesia for a cholecystectomy. The drug is discussed in terms of preoperative, intraoperative, and immediate postoperative effects. During the preoperative phase, no effect was demonstrated. Intraoperatively, t...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Bioallied Sciences
سال: 2012
ISSN: 0975-7406
DOI: 10.4103/0975-7406.94117